(Non-Dispersive Infrared (NDIR)+ laser diffraction techniques)
Additive manufacturing, also known as 3D printing, is an approach that allows fabrication of complex metallic parts or geometrical shapes by depositing metal powder layer-upon-layer. It lends control to engineers for prototyping and shortens lead-time for parts.
The quality of the powder determines the quality of the final product. This is especially true when the process also involves powder recycling to limit waste and improves efficiency. Since recycling increases the risk of contamination and subsequently modifies the material characteristics, it is critical to assess and monitor key quality attributes including particle size, shape, degree of powder agglomeration and purity over time.
In this webinar, Dr. Anderson Bonon and Dr. Matthieu Chausseau will use laser diffraction, image analysis, X-ray fluorescence and elemental analysis (C/S, O/N and H) to demonstrate effective control of the raw material as well as recycled powder. Case studies obtained from various powders commonly used in processes will be discussed with a Q&A session to follow.
What you will learn:
(Raman Spectroscopy + laser diffraction techniques)
Pharma particles range from suspension droplets in a liquid formulation to dry particles used in solid dosage forms. The effectiveness of a formulation depends on both the size distribution and chemical composition of these particles. Here, we present two complementary analysis methods. Raman microspectroscopy is an excellent probe of particle composition and particle size. Laser diffraction is a workhorse technique for particle size determination and offers precision and speed.
Join Dr. Jeff Bodycomb and Dr. Eunah Lee as they discuss using both of these techniques for analyzing pharmaceutical powders and emulsions and comment on how they fit together.
(Fluorescence and Absorbance Spectrometer + dynamic light scattering techniques)
The effectiveness of all water and wastewater treatment processes is impacted by organic matter. No single treatment method can remove all the types of organic carbon present in these waters, and methods of improved characterization of organic matter are therefore needed at various stages of water and wastewater treatment. While surrogate measures of UVA254, total and dissolved organic carbon (TOC/DOC), and chemical oxygen demand (COD) indicate trends, they inadequately portray the character and composition of the organic matter removed and/or transformed at each treatment stage or reuse process.
Advanced instrumentation drives organic matter characterization in water and wastewater treatability. A suite of HORIBA instruments is used at the Brown and Caldwell Water Treatability Laboratory in Nashville, Tennessee to characterize aqueous organic matter. Excitation-emission matrix fluorescence spectroscopy (EEM) combined with PARAllel FACtor (PARAFAC) analyses, zeta-potential determination, and particle size distribution measured with dynamic light scattering (DLS) and laser diffraction (LD) techniques are applied to monitor diagenetic (degraded and rearranged fulvic and humic acids) and biogenic forms of organic carbon. The supramolecular aggregation of nonliving organic matter which complicates water treatability and its analytical measurement, and examples of these techniques will be presented.
Drs. Katherine Y. Bell, (Director of Water Strategy), and Martha J.M. Wells (Chemical Consultant to Brown and Caldwell) will co-present this webinar. Kati will provide an overview of water treatment at Brown and Caldwell and what services are offered. Martha will provide the fundamentals of the technologies applied and a discussion of our current understanding of organic matter aggregation in water.
What you will learn:
Who would benefit from attending:
(Fluorescence Spectroscopy + laser diffraction techniques)
Cannabidiol (CBD) is used in a variety of commercial products, from dietary supplements, to food and beverages and cosmetics. Potency, particle size, and stability all play an important role in the quality control, regulation, and efficacy of CBD/Hemp emulsions.
In recognition of the need for standards and regulation of this rapidly growing market, US lawmakers have drafted the CBD Product Safety and Standardization Act of 2021 that would set standards for hemp-derived CBD in food, and direct FDA to issue regulations for labeling and packaging requirements, as well as conditions of use. This bill, coupled with draft legislation controlling CBD in dietary supplements, will provide the framework to define future testing requirements.
In this webinar, we describe current guidance from FDA, and describe novel, cost effective approaches from HORIBA that address several testing needs of emulsions. We specifically target these challenging samples, as standard chromatography methods are often inadequate in capturing the necessary parameters that determine product quality – specifically potency and emulsion particle size range.
For potency determination, we present a fast and accurate approach using the A-TEEM method on HORIBA’s Aqualog spectrometer. We will also illustrate how emulsion particle size impacts sample stability and efficacy, using the HORIBA LA-960V2 laser diffraction particle size analyzer. These systems provide rapid and effective information that will be important within the future regulatory framework for CBD products.
(Raman Spectroscopy + Particle Characterization)
Battery electrodes (both anode and cathode) present an array of analysis challenges. Starting with raw materials, the particle size distribution will have an effect on finished product performance. And evaluation of changes in anodes and cathodes along with evaluation of separator materials is critical to understanding and optimizing performance. In this webinar, Drs. Jeff Bodycomb and Sergey Mamedov talk about particle analysis and spectroscopic techniques (Raman and XRF) for evaluating these important components that power 21st century technology. They describe a range of techniques and give examples of their practical application.
Topics covered include:
(Fluorescence Spectroscopy + Multi-laser Nanoparticle Tracking Analysis Technique)
Vaccine development is quite challenging, with products consisting of multiple components at very low concentrations. There is a need for robust and rapid analytical tools throughout the product lifecycle: from formulation development with a focus on creating drug products with increased efficacy and stability, to manufacturing where final product needs to be screened for potency and purity. To meet recent surge in demand, we must think outside the box from traditional analytical methods.
Join our webinar to hear experts in the field, Dr. Kevin Dahl of Particlese LLC and Dr. Linda Kidder of HORIBA Scientific provide tips and alternative solutions for better vaccine development and quality. They will discuss the application of multi-laser nanoparticle analysis (NTA) in determining vaccine degradation and total particle count. They will also present a new analytical approach, fluorescence A-TEEM (Absorbance - Transmittance Excitation Emission Matrix) method for rapid screening of similar but different vaccine final formulations.
What will the audience learn?
• Analytical tips from a former Analytical Director at a CDO.
• Why measuring virus aggregation and complex formation is important and how multi-laser NTA plays a part in this process.
• How the A-TEEM method works by combining UV/Vis and Fluorescence EEMs spectroscopy to detect very low concentration components in complex mixtures.
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