LabRAM Soleil

LabRAM Soleil Raman Microscope full view

Raman Microscope

Your ideal lab companion

The result of 50 years of expertise in Raman spectroscopy, LabRAM Soleil™ offers unprecedented capabilities for Raman multimodal confocal imaging, in a compact footprint.

Due to the high level of automation implemented, high optical throughput, objective recognition, motorized switching mirrors, ultra-fast mapping capabilities with SmartSampling™ and QScan™, fast motorized 4-grating turret, high speed auto-alignment and new options offered by the LabSpec 6 software suite, the LabRAM Soleil™ is ready to work 24 hours a day with minimal human supervision.

Segment: Scientific
Manufacturing Company: HORIBA France SAS

Multimodal Confocal imaging in a compact footprint

LabRAM Soleil™ offers great variety of optical viewing modes and hyperspectral imaging features in a compact and laser safe design:

  • < 1m² footprint
  • Large Class 1 sample compartment
  • Reflection (episcopic) /transmission (diascopic) illumination
  • Imaging in optical microscopy bright field/dark field/epifluorescence/phase and differential interferometric contrast (DIC)
  • ViewSharp 3D Topography
  • QScan™ high quality scanning technology for 3D confocal imaging with Laser light-sheet illumination - mapping without moving
  •  XYZ 3D confocal imaging, Z-profile (single-point or layer by layer with QScan™ option)
  • Super-low frequency (30 cm-1) Raman scattering as standard
  • Photoluminescence (PL), electroluminescence, photocurrent, upconversion
  • Nanoscale spectroscopy: NanoRaman (TERS), NanoPL, and Cathodoluminescence with our AFM and SEM extensions


Focus on your job, it takes care of the rest!

Forget long and tedious preparation operations before getting your Raman image. LabRAM Soleil™ offers advanced automated functions and, in combination with the EasyImage™ wizard, it dramatically reduces parameter setting time and ensures maximum stability and reproducibility:

  • True self-operating system
  • EasyImage™ guided operation wizard
  • Auto-alignment: automatically check and readjust the alignment within a few seconds according to environmental conditions
  • SmartID™: no more risk to use the wrong objective or wrong parameters
  • Remote maintenance


Ultrafast imaging: Raman imaging has never been so fast!

Due to a higher optomechanical stability, advanced and patented video Raman matching technology, LabRAM Soleil™ makes possible high-quality Raman imaging up to 100 times faster than a conventional Raman spectrometer.

  • SmartSampling™: New mapping algorithm, acquiring most contributive points first, is turning hours maps into minutes.
  • TurboDrive™: Fast grating turret drive - up to 400 nm/s
  • 4 different SWIFT™ functions:
    • SWIFT
    • SWIFT™ XS: Ultra Mode: Fast Raman imaging: up to 1400 spectra/s - High Contrast Mode: fast readout rates and enhanced signal
    • SWIFT™ XR: Fast large spectral range acquisitions using Multi Windows mode
    • Repetitive SWIFT™: Continuously improve the S/N ratio over time


Facing all analytical challenges:

From materials studies to polymers, and biological to pharmaceutical laboratories, LabRAM Soleil™ can be easily adapted for each application.  Its advanced modularity and flexibility makes it a perfect Raman microscopy system, for both academic research laboratories and industrial quality control departments.

  • Up to 4 internal lasers and 6 different filters
  • 4-grating turret exchangeable in less than a minute
  • Super-low frequency as standard: down to 30 cm-1 Raman shift
  • Large sample compartment: 444(H) x  509 (L) x 337 (W) mm
  • High robustness and simplified maintenance operation


LabSpec6 software: harness LabRAM Soleil full power with ease!

LabSpec 6 software offers a great modularity with the exclusive LabStore Apps. Any user can configure his software according to his own needs. Efficiency and performance are combined with ease-of-use. The modern and intuitive design of the software makes it easier than ever to achieve a perfect Raman image. No need to be an expert anymore.

  • Advanced Multivariate analysis MVAPlus™ : Process megapixel datasets with ease and maximum accuracy for molecule identification and quantitation, even with “difficult” samples
  • ProtectionPlus ensures compliance with FDA 21 CFR Part 11 and GMP/GLP requirements
  • ParticuleFinder™ automatically combines morphological and chemical analysis to classify particles in seconds
  • EasyImage™ automated workflow to obtain Raman image in a single click
Wavelength rangeUV-VIS-NIRBroadband high troughput achromatic mirror based system, optimized from 300 nm to 1600 nm without changing optics.
Standard Laser Wavelengths325, 405, 473, 532, 638, 785 nmTypical lasers for Raman and PL. Other wavelengths upon request.
Spectrometer scanning speedUp to 400 nm/sWith 600g/mm grating, mounted on standard Turbodrive 4-grating turret, for fast Raman, PL and upconversion luminescence spectral map acquisitions.
Number of gratingsunlimited4-grating exchangeable motorized turret.
Fast Imaging<1ms/spectrumSWIFT, SWIFT XS EMCCD, SWIFT repetitive, SWIFT eXtended Range and SmartSampling for ultrafast imaging.
3D confocal slicing with laser lightsheet illuminationQScan (patent)Typical 2 μm thick 100 x 100 μm2 laser lightsheets for large area 2D/3D confocal imaging.
Low wavenumber cut-off5 cm-1With optional VBG filters, >70% transmission.
Standard wavenumber cut-off30 cm-1With edge filters for 532, 638 and 785 nm wavelengths, injection rejection, >99% transmission.
High wavenumber cut-off for PL1600 nmScanning Czerny Turner spectrometer with 2 motorized detector ports for CCD and InGaAs array detectors.
Laser auto-alignment procedure15 sOptional ultrafast sample-independant laser auto-alignment allowing remote maintenance.
Built-in lasersUp to 4 Solid-state lasersNUV to NIR wavelengths available.
External lasersUnlimitedFor large gas and ultrafast lasers typically.
Spectroscopic motorized modalitiesUp to 6 laser filtersRaman, PL, ULF, Upconversion luminescence…
Rayleigh Filter orientationIndividual filter computer controlledFactory preset & user adjustable angle to adapt with sample reflectivity.
AFM / SEM couplingYesBuilt-in horizontal exit for direct Atomic Force Microscope coupling, optional fiber entrance for SEM coupling with RCLUE.
Operating temperature range18-28 °CNon condensing
Dimensions (W x D x H in mm)
Weight (kg)

898 x 797 x 806
120 kg

~1 cubic meter, including lasers, CDRH enclosure, electronics and cooling to save space in your laboratory
Power consumption< 600 W for a fully loaded configurationEco-friendly and safe design, with built-in class 1 enclosure, low power consumption electronics and cooling, 1 power cable EU / US type
Three Dimensional Raman Imaging
Three Dimensional Raman Imaging
Segmented channel waveguides have been fabricated in single crystal KTiOPO4 through a topotactic process of partial cation exchange. The ion-exchanged waveguides maintain the high nonlinear susceptibility of KTiOPO4 to function as frequency doubling laser light sources. We apply three dimensional (3D) Raman imaging to understand and characterize the changes to the chemical bonding and crystalline structure as well as measure the volumetric structure of the waveguide segments.
Pharmaceutical compounds distribution and cosmetic products analyzed by confocal Raman spectroscopy
Pharmaceutical compounds distribution and cosmetic products analyzed by confocal Raman spectroscopy
In the final step of the formulation process, pharmaceutical and cosmetic industries have to control their products to check if the compounds' distribution in the final product, or in its application form, i.e. dispersed on a skin for an intracutaneous product, are homogenous and stable in order to guarantee the product's efficacy. In this paper, we present why confocal Raman microscopy is an excellent tool for product characterization after formulation.
Structural characterization of WS₂ flakes by Photoluminescence and ultra-low frequency Raman spectroscopy on a unique multimode platform
Structural characterization of WS₂ flakes by Photoluminescence and ultra-low frequency Raman spectroscopy on a unique multimode platform
2D materials are state-of-the-art in nano- and opto-electronics. Characterizing their structural properties with a non-destructive approach at the micron scale is very important. We demonstrate in this paper how LabRAM Soleil™ confocal Raman multimode microscope is the perfect tool for these materials characterization.
Raman microscopy applied on polymers characterization: An overview
Raman microscopy applied on polymers characterization: An overview
Raman microscopy is an excellent tool to address the polymer research. Raman microscopy can be used to characterize raw materials, to inline or outline monitor polymerization process, to investigate orientation and crystallization changes, and also to control the quality and traceability of genuine products, by understanding defects and compounds distribution. In this article we present how HORIBA Raman microscopy solutions can support the polymer chemical and structural understanding.
Polymorphisms characterization: when Raman microscopy supports the pharmaceutical industry
Polymorphisms characterization: when Raman microscopy supports the pharmaceutical industry
Polymorphisms characterization of active molecules is one piece of important information for the pharmaceutical industry, not only on raw powders, but also in the final form. Raman microscopy remains the most appropriate solution for this application. In this paper, we present an example of polymorphisms characterization by Raman microscopy using the super low frequency module.
Identification and characterization of aeroallergens based on morphological and chemical features
Identification and characterization of aeroallergens based on morphological and chemical features
The prevalence of allergies in the world is between 30 and 40%. Even though it exists medical treatments such as antihistaminic and desensitization this number is constantly increasing. Thus, in this application note, the identification and chemical characterization of aeroallergens by Raman microscopy will allow to prevent people who are affected by respiratory allergies of the presence of this type of allergens in indoor and outdoor air.
Morphological and chemical characterization of pharmaceutical formulations
Morphological and chemical characterization of pharmaceutical formulations
In order to control formulations of pharmaceutical products, characterizing their active compounds is critical, especially in terms of morphological and chemical characterization of particles. In this application note, two formulations from a generic and an innovator nasal spray have been analyzed to compare their compounds size and shape, and chemically characterized to compare the two formulations based on the ParticleFinderTM app for LabSpec 6. A focus is done on the active compound.
Milk compounds characterization by optical spectroscopies and laser diffraction
Milk compounds characterization by optical spectroscopies and laser diffraction
In the food industry, the compounds characterization is a critical step to ensure the quality of the products or to provide information to customers which can be sensitive to allergies. In this application note, we showed how optical spectroscopies and laser diffraction can help for food compounds characterization, especially on a specific product, i.e. milks.
Morphological and chemical characterizations of microplastic particles using ParticleFinderTM and Raman techniques
Morphological and chemical characterizations of microplastic particles using ParticleFinderTM and Raman techniques
The assessment of microplastics in a marine environment is a multi-step process (sampling, extraction, detection and quantification of microplastics), in which each step is time consuming. Analyzing the chemical composition and morphology of microplastics represents a real challenge for answering crucial questions about the sources and fate of microplastics in aquatic environments. In this application note, we present a reproducible and time-effective method for fast and thorough morphological and chemical characterization of microplastics using a semi-automated scanning of particles coupled to micro-Raman spectroscopy. The rapid analysis of large number of collected particles allows for an exhaustive assessment of both large sample sizes and small subsamples.
Valuable analysis tool for cosmetics and skin characterization
Valuable analysis tool for cosmetics and skin characterization
Confocal Raman Spectroscopy is an important analytical tool in various fields and it has shown high efficiency for specific applications in the cosmetic and/or pharmaceutical fields. Its non-invasive behavior, and its high molecular sensitivity make it one of the preferred label-free analytical techniques to characterize materials such as skin and cosmetic products.
Strain Measurements of a Si Cap Layer Deposited on a SiGe Substrate, Determination of Ge Content
Strain Measurements of a Si Cap Layer Deposited on a SiGe Substrate, Determination of Ge Content
Raman spectroscopy is a very well suited technique to determine both Ge fraction and strain in SiGe layers and Si cap layers. Moreover the possibility of using both UV and visible excitation lines on the same instrument is essential to study structures made up of a Silicon cap layer on top of a SiGe layer. The relative Ge content in the constant Si1-xGex layer is calculated from the visible Raman spectrum and the strain of the cap Si layer is derived from the UV Raman spectrum.
Real-time Monitoring of Polymerisations in Emulsions by Raman Spectroscopy - Modelling and Chemometrics
Real-time Monitoring of Polymerisations in Emulsions by Raman Spectroscopy - Modelling and Chemometrics
Raman spectra, in conjunction with Multivariate (Chemometric) Analysis, have been demonstrated to provide real-time information on the progress of a polymerisation reaction. As shown by this example, these results can provide unexpected information on the details of the reaction. in this case, the inequivalent reaction rates of the two monomers. Such information ultimately enables the process engineer to optimise his process.
Using Chemometrics and Raman Spectra for Quantitative Predictions of Physical and Chemical Properties of Polymers
Using Chemometrics and Raman Spectra for Quantitative Predictions of Physical and Chemical Properties of Polymers
As far as polymeric fibres are concerned, slight modifications of Raman features are directly related to differences in the molecular orientation and the degree of crystallinity of the fibres. To utilize these subtle spectral changes and correlate them with physical properties of the polymer, one is obliged to use Chemometrics on the Raman spectra. The resulting synergism between Raman spectroscopy and Chemometrics will provide a powerful tool for monitoring and control of manufacturing of polymeric materials.
Transmission Raman Spectroscopy: Review of Applications
Transmission Raman Spectroscopy: Review of Applications
The transmission design has demonstrated to be the technique of choice whenever Raman spectral information of a bulk material is required. It has already proven its utility for pharmaceutical applications, as tablets or even powder mixtures are good candidates for this measurement mode. However, transmission Raman might be applied successfully to other sample types, such as polymers, bio-tissues or any translucent material, and can be envisaged for evaluating the content of product inside a package. In addition, as TRS provides a global spectral information of the measured sample, it will be a technique of choice when quantitative evaluation of mixtures is needed.
Raman Imaging of Holographic Gratings Inscribed on Polymer Thin Films
Raman Imaging of Holographic Gratings Inscribed on Polymer Thin Films
Using holographic techniques we have structured the surface in a one step procedure (no wet nor photocuring processing ) along the X and Y directions. A grating is first inscribed with grooves along the X direction, the sample is rotated by 90° and a second grating is inscribed with grooves along the Y direction. The intensity of the 1st diffracted orders is monitored to have equal intensities in both X and Y directions.
Raman Characterization of Polymers in Industrial Applications
Raman Characterization of Polymers in Industrial Applications
Recent developments in Raman instrumentation have made the technique easier to use, more compact, and more affordable. Consequently, all of the demonstrated potential of the spectroscopy for industrial uses can now be exploited, including its use in combination with statistical methods for concentration calibrations.
Localisation of Polymeric Phases by Raman Microscopy Mapping Components of a Blend in a Plane and Depth Profiles of Laminated Film
Localisation of Polymeric Phases by Raman Microscopy Mapping Components of a Blend in a Plane and Depth Profiles of Laminated Film
Blending, an alternative method for engineering products that combines the properties of polymer types is a physical mixing. It has the advantage of being not only simple and inexpensive, but also allows for re-cycling used material. Incompatibility or non-miscibility of the differing chemical components is often an issue in the final performance of the polymer product. The first part of this note concerns the dispersion of the two components in a polyethylene-polybutylene terephthalate blend. The chemical imaging capabilities of the LabRAM are used to get this information. The second part deals with the depth analysis of laminated films made of different polymer layers.
Concentration Profile Measurements in Polymeric Coatings During Drying by Means of Inverse-Micro-Raman-Spectroscopy
Concentration Profile Measurements in Polymeric Coatings During Drying by Means of Inverse-Micro-Raman-Spectroscopy
The coupling of the power of confocal Raman microscopy to the inverted sampling geometry has enabled detailed investigations to be made of solvent and water based coating systems, providing important information on the processes and chemistry that occurs at the coating interface and within.
The non destructive and in-situ analysis of pigments
The non destructive and in-situ analysis of pigments
Archaeometric analysis of ancient pottery
Archaeometric analysis of ancient pottery
Archaeometric analysis of ancient pottery in a church
Archaeometric analysis of ancient pottery in a church
Observing Oxidating Kinetics on an aluminium alloy surface with Fluorescence mapping
Observing Oxidating Kinetics on an aluminium alloy surface with Fluorescence mapping
Characterization of MoS2 Flakes using TEOS
Characterization of MoS2 Flakes using TEOS
Both TEPL and TERS images are well correlated with AFM morphological images obtained simultaneously, and all are consistent in revealing the nature (number of layers) of MoS2 flakes. Upon deconvolution, the TEPL signal is even capable of revealing local inhomogeneities within a MoS2 flake of 100 nm size. Kelvin probe measurement supports TEPL and TERS measurements and adds to the power of such tip-enhanced combinative tools. TEOS characterization of 2D materials is likely to contribute to further deployment of these materials into commercial products through a better understanding of their electrical and chemical properties at the nanoscale.
Combined Raman and Photoluminescence Imaging of 2D WS2
Combined Raman and Photoluminescence Imaging of 2D WS2
Raman and photoluminescence spectroscopy reveal different aspects of the solid state structure of 2D materials. Raman and photoluminescence imaging performed simultaneously with one instrument reveals the spatial variation of the solid state structure and electronic properties of 2D crystals that is not revealed in reflected white light imaging. That ability should allow materials scientists to better design and fabricate electronic and optoelectronic devices based upon 2D crystals.
Number of Layers of MoS2 Determined Using Raman Spectroscopy
Number of Layers of MoS2 Determined Using Raman Spectroscopy
The two methods - Analysis of fingerprint modes (intralayer) and Analysis of low-frequency modes (interlayer) - give complementary results and allow the determination of the number of MoS2 layers. Method 2 (using low frequency modes) gives excellent contrast; however it does not show single layer regions (which is related to the nature of the modes, rising from interaction between at least two layers). Method 1 (using fingerprint modes) shows all the layers, but the contrast is poorer, particularly for higher numbers of layers. The best result can be obtained combining the two methods. All the measurements (low-frequency and fingerprint) were done using ultra-low frequency ULFTM filters which allow a high throughput measurement in a full Raman range, down to <10 cm-1.
Impact of Raman Spectroscopy on Technologically Important Forms of Elemental Carbon
Impact of Raman Spectroscopy on Technologically Important Forms of Elemental Carbon
The Raman spectra of the various forms of elemental carbon are very sensitive to the type of nearest neighbour bonding, and to intermediate and long range order. In many cases Raman spectroscopy is the technique of choice for characterization of carbon materials. Correlation of Raman spectral features with tribological properties can facilitate the deposition of carbon films.
SWNT Quality Control by Raman Spectroscopy
SWNT Quality Control by Raman Spectroscopy
Raman has shown a high potential in characterising the SWCNTs' structure. The correlation between knowledge about structure with physical and chemical properties about the tubes make the technique extremely powerful to control the quality of the SWCNTs for specific applications. Raman spectrometer capabilities like spatial resolution, spectral resolution and excitation wavelength versatility have been examined. Beside Raman, preliminary fluorescence studies are describing the potential of the technique.
Graphene Studies using Raman Spectroscopy
Graphene Studies using Raman Spectroscopy
Graphene is a new nanomaterial which may partially replace silicon in microcircuits and computer chips in the future. In order to better understand its quality characteristics, fast reliable techniques that deliver the right property measures are needed. Raman spectroscopy has emerged as a key technique for studying this exceptional material.
Derivation of Physical Parameters from Raman Spectra of Hard Carbon Films
Derivation of Physical Parameters from Raman Spectra of Hard Carbon Films
The Raman spectra of elemental carbon materials are known to be sensitive to polymorphy. For hard carbon films, the spectra of amorphous and diamond-like carbons can be band-fit to separate the contributions of the "graphitic carbon" (G band) from the "disordered carbon" (D band). The spectral behaviour of carbon films has been empirically correlated with thin film physical properties such as hardness, durability, optical transparency, electrical conductivity, thermal conductivity and corrosion resistance, and can be of use for prediction of these properties without extensive alternative testing. The DiskRam has been designed to automate the collection of Raman spectra from hard carbon coatings on computer hard disk media and the extraction of parameters that are well correlated with the properties of the films. The extracted information is output in spreadsheet format for SPC at a manufacturing facility.
Coloured Diamond Defect Idenditication by Raman Diffusion and Photoluminescence
Coloured Diamond Defect Idenditication by Raman Diffusion and Photoluminescence
The colour enhancement treatment on native brown and yellow diamonds can be highlighted by Photo Luminescence analyses performed with the Raman spectrometer LabRAM HR. The PL signature of green and violet diamonds has also been recorded. The defect centres responsible of the colour of the diamonds have all been detected and assigned. This proves the Raman spectrometer to be a very good tool to investigate the fine defects in the Diamond structure by Photoluminescence analysis.
Microscopic Measurement of Diffusion
Microscopic Measurement of Diffusion
In order to engineer materials with controlled diffusive properties, we need to be able to measure the diffusive process in situ. Ideally, we would like a technique that provides molecular information with resolution on a microscopic scale, that is non destructive of the samples, and can be set up and used on a laboratory bench top with a minimum of time and effort involved in sample preparation. Raman microprobe spectroscopy is an ideal candidate for this type of studies. Use of visible light combined with a confocal microscope provides a probe with spatial resolution of a micron or better, and coupling of such a microscope to a modern Raman spectrometer equipped with holographic notch filters and CCD multi channel detectors allows rapid acquisition of Raman spectra which can be correlated with the chemical state of the species and its physical environment.
Pharmaceuticals_under_humidity_controlled_atmosphere
Pharmaceuticals_under_humidity_controlled_atmosphere
Raman Microscopy in Pharmaceutical Salt Analysis
Raman Microscopy in Pharmaceutical Salt Analysis
Pharmaceutical and crystallographic samples typically require detailed characterization and analysis to optimize a samples stability, physical properties and indeed general efficacy where an active drug substance is involved.
Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids
Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids
Raman Analysis and characterization of pharmaceuticals
Raman Analysis and characterization of pharmaceuticals
Polymorphy in pharmaceuticals by Raman Spectroscopy
Polymorphy in pharmaceuticals by Raman Spectroscopy
In Vivo Raman measurements of Human Skin
In Vivo Raman measurements of Human Skin
Confocal Raman spectroscopy is beginning to be recognized as a high potential technique for the non invasive study of biological tissues and human skin under in vivo conditions. Raman spectroscopy can be applied to obtain information regarding the molecular composition of the skin down to several hundred micrometers below the skin surface.
Soap_compound_investigation_by_Raman_mapping
Soap_compound_investigation_by_Raman_mapping
Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
Char of Compounds in a pharmaceutical drug product
Char of Compounds in a pharmaceutical drug product
SERS Analysis of single living lymphocytes
SERS Analysis of single living lymphocytes
Raman Analysis of Sperm Nuclear DNA Integrity
Raman Analysis of Sperm Nuclear DNA Integrity
Raman Spectroscopy was evaluated as a non-invasive method of analysis of sperm DNA and the influence of UV irradiation on the sperm. The results show that Raman Spectroscopy, combined with multivariate analysis provide the reproducible and accurate information on DNA of sperm and the effect and location of damage.
Raman Imaging of monkey brain tissue
Raman Imaging of monkey brain tissue
Fast and non-invasive methods for clinical and non clinical investigations for biological tissue are more and more required. Raman imaging at micro scale can answer to crucial questions about the monkey brain tissue morphology and structural evolution.
Raman Investigation of Micro-organisms on a single cell level
Raman Investigation of Micro-organisms on a single cell level
Raman Analysis of Single Bacteria Cells
Raman Analysis of Single Bacteria Cells
Traditionally, Raman has been a technique of the material scientist, physicist or chemist, but as instrumentation continues to evolve, the power of Raman in biological and medical applications is fast being realized, not least because of the high information content provided and an excellent tolerance for water.
Direct_identification_of_clinically_relevant_microorganisms
Direct_identification_of_clinically_relevant_microorganisms
Insights into thrombosis mechanisms using high resolution SERS
Insights into thrombosis mechanisms using high resolution SERS
Raman Spectroscopy Applied to the Lithium-ion Battery Analysis
Raman Spectroscopy Applied to the Lithium-ion Battery Analysis
The application note explains how the Raman Spectroscopy can be helpful in the analysis of cathodes and anodes in Li-ion batteries. Today’s state of art of technology requires more reliable, more efficient and powerful energy sources. Lithium-ion batteries are thus of high interest. Raman spectroscopy adapts to the different stages of life of these batteries, such as the characterization of new materials for more flexible systems, failure analysis; but also more standard analysis of used material during charge/discharge process, including structural and electronic properties, and even robust, automated QC tests.

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