Analyze nano- and bio-materials faster and easier with Raman microscopy featuring EDF and HSI from CytoViva.

• Benefits of enhanced darkfield (EDF) microscopy:
  CytoViva’s patented enhanced darkfield technology, including the enhanced darkfield condenser and the dedicated illumination unit, improves the signal noise ratio up to ten times over the standard darkfield microscopy.  Detection limit for the target size is increased, enabling the visualization of nanoparticles as small as 10 nm when isolated in solution, cells and/or tissues.  Images obtained are much cleaner, crisper and more accurate than those obtained with the standard darkfield microscopy, optimizing darkfield detection capability for non-fluorescing nanoscale samples.
   
• Benefits of hyperspectral imaging (HSI) microscopy:
  Hyperspectral imaging (HSI) microscopy is designed to acquire optical spectra at every point in the image across the visible and near infrared regions (typically 400 nm – 1000 nm) of, for example, bio- and nano-materials such as nanoparticles distributed in cells or tissues.  It takes only minutes to acquire a hypercube (a high spatial resolution image composed of tens of thousands of optical spectra).  It is straightforward to detect and potentially differentiate, for example, nanoparticles in biomaterials based on their optical spectra.  The user can then identify the region of interests for chemical analysis with Raman microscopy.  The analysis becomes much faster and more efficient by utilizing both (and more) technologies.
   
• Benefits of the integrated system:
  There is absolutely no need to transfer the sample between microscopy technologies (e.g. brightfield, epi-fluorescence, enhanced darkfield, etc.), illumination modes (e.g. reflected and transmitted illumination), or hyperspectral imaging technologies (e.g. Raman, photoluminescence, optical microscopy, etc.), ensuring all of these multimodal images are truly of the same position.