Utilizing A-TEEM Technology for In-Process Monitoring of Monoclonal Antibody Production

Monoclonal antibodies (mAbs) are lab-produced molecules designed to mimic the immune system’s ability to recognize and bind to specific targets, such as viruses, bacteria, or cancer cells. Monoclonal antibodies as proteins are composed of amino acids. Some amino acids, specifically tyrosine, tryptophan and phenylalanine are intrinsically fluorescent. This, therefore, allows fluorescence spectroscopy to be used to monitor structural and environmental changes in monoclonal antibodies, making it a valuable tool for their characterization and quality assessment during manufacturing.

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Utilizing A-TEEM Technology for In-Process Monitoring of Monoclonal Antibody Production
In this paper, HORIBA presents evaluation work from CPI showing A-TEEM as a suitable technique to analyze six in-process manufacturing samples of monoclonal antibodies. This work is an initial step toward implementing this technique as a PAT solution in biologics manufacturing.
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