Spectroscopic Ellipsometric measurements on biochip structures in a liquid flow cell environment

The sample described here were DNA 35 base fragments thiol-grafted deposited on a thick gold layer. Although this experiment can be performed in air it is important to study such samples in a biosensor configuration, where the desired interaction between the grafted DNA and different analyte solutions can be characterised. The performance of the UVISEL Sepctroscopic Phase Modulated Ellipsometer allows very sensitive and selective study of the kinetics and quantification of such interactions.