農産物の収穫直前に散布される主な農薬（殺虫剤と殺菌剤）21種類について，直接競合ELISAを利用した測定キットを開発した。農薬などの低分子性物質は，それ自体に抗体産生能がないが，免疫原性を持つタンパク質表面に共有結合し接種することで抗体を産生する場合がある。このような物質をハプテンといい，農薬に対する抗体もこの性質を利用して調製した。まずハプテン設計や抗体調製の基礎的検討を行い，モノクローナル抗体が対象農薬と高い反応性を示すほか，有機溶媒耐性など農薬分析に有効な反応特性を示すことを見出した。これらの知見に基づいて開発した農薬測定キット「SmartAssay（スマートアッセイ）シリーズ」は，農産物中の残留農薬測定に適用可能との評価を得，農産物の出荷前検査に利用されている。
Twenty one kinds of direct competitive ELISA test kits were developed for checking insecticides and fungicides. The pesticides are applied just before harvests. Low molecular compounds including pesticides do not have an antibody by producibility themselves. However, some of them produce antibody by binding covalently to the surface of immunogenics protein to innoculate. These compounds are called hapten and anti-pesticide antibodies were also prepared by this behavior. In the basic examinations of hapten design and antibody preparation, it was found that monoclonal antibodies showed higher reactivity to the pesticides than polyclonal antibodies and efficient reaction property to pesticide analysis such as tolerance to organic solvent. Pesticide residue analysis test kits “SmartAssay series” developed based on such a knowledge have been evaluated by researchers as applicable to residual pesticide analysis in farm products. The kits are used for pesticide test before shipment.