Brief Biography
Fiona holds a BSc (Physics/Chemistry) from Trinity College Dublin and a PhD from University College Dublin. She has held postdoctoral research positions at Daresbury Laboratory UK, University College Cork and DIT and is currently Head of the DIT Centre for Radiation and Environmental Science and leads a team of 15 researchers. She has published over 90 peer reviewed research papers and has filed 3 patents. She has supervised over 20 PhD students to completion and has successfully won over €2.5 million in research funding. She won the Enterprise Ireland ‘One to Watch’ Award in 2011.  Fiona is currently Past President of the Microscopy Society of Ireland and Past Chair of the Irish Radiation Research Society.  She is a member of the management committee and a working group leader for the COST Action Raman4Clinics.

Academic Qualifications
BSc (Hons.) 1st Class Hons in Physics and Chemistry, Awarded by Trinity College Dublin (1991)
PhD, Awarded by University College Dublin  (1995)

Current Appointment and Previous Positions

  • Oct 2003 - present  Head, RESC, Dublin Institute of Technology
  • Jan 1999 – Sept 2003  Senior Postdoctoral Research Fellow, RESC, Dublin Institute of Technology
  • June 1998 - Jan 1999   Postdoctoral Research Fellow, Awarded by the Health Research Board at Cellular Physiology Research Unit, University College Cork
  • Oct 1995 - May 1998  Postdoctoral Research Fellow, Awarded by the Ernst Schering Research Foundation Synchrotron Radiation Dept, Daresbury Laboratory, U.K.

Recent Relevant Publications (from total of over 90 peer reviewed journal publications)

  • Carvalho LFCS, Bonnier F, O´Callaghan K, O´Sullivan J, Flint S, Byrne HJ and Lyng FM, Raman micro spectroscopy for rapid screening or oral squamous cell carcinoma and dysplasia, Exp Mol Pathol 2015 doi: 10.1016/j.yexmp.2015.03.027
  • Maguire A., Vega-Carrascal I., Bryant J., White L., Howe O., Lyng F. M. and Meade A. D. , Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy Analyst 2015 140(7):2473-81. doi: 10.1039/c4an01887g.
  • Maguire, A. ,Vegacarrascal, I. , White, L. , Howe, O. , Lyng, F.M., Meade, A.D. Analyses of low dose ionising radiation effects ex – vivo in peripheral blood lymphocytes with Raman spectroscopy. Radiat. Res.  2015 (in press)
  • Ramos IRM, Malkin A, Lyng FM, Current advances in the application of Raman spectroscopy for molecular diagnosis of cervical cancer, BioMed Research International 2015 (in press)
  • Lyng FM, Ramos IRM, Ibrahim O, Byrne HJ. Vibrational Microspectroscopy for Cancer Screening. Applied Sciences. 2015; 5(1):23-35, doi:10.3390/app5010023
  • Rashid N., Nawaz H., Poon K.W.C., Bonnier F., Bakhiet  S., Martin C.,  O’Leary J.J, Byrne H.J. and. Lyng F.M. Raman microspectroscopy for the early detection of pre-malignant changes in cervical tissue. Exp Mol Pathol 2014  97(3):554-64. doi: 10.1016/j.yexmp.2014.10.013
  • Bonnier F, Traynor D, Kearney P, Clarke C, Knief P,  Martin C,  O'Leary JJ, Byrne HJ  and Lyng F, Processing ThinPrep cervical cytological samples for Raman spectroscopic analysis, Anal. Methods, 2014, 6, 7831
  • Nawaz H, Garcia A, Meade AD, Lyng FM, Byrne HJ. Raman micro spectroscopy study of the interaction of vincristine with A549 cells supported by expression analysis of bcl-2 protein. Analyst. 2013 Oct 21;138(20):6177-84.
  • S. M. Ali, F. Bonnier, K. Ptasinski, H. Lambkin, K. Flynn, F.M. Lyng, H.J. Byrne, Raman Spectroscopic mapping for the analysis of solar radiation induced skin damage, Analyst, (2013) 138(14):3946-56
  • S.M. Ali, F. Bonnier, H. Lambkin, K. Flynn, V. McDonagh, C. Healy, T.C. Lee, F.M. Lyng, H.J. Byrne, A comparison of Raman, FTIR and ATR-FTIR micro spectroscopy for imaging human skin tissue sections, Analytical Methods, 5, 2281-2291 (2013)

Raman spectroscopy for cervical cancer screening and diagnosis

DIT Centre for Radiation and Environmental Science, Focas Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland

Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if this disease is detected at the pre-cancer stage (cervical intraepithelial neoplasia, CIN). Current gold standard methods include cytology and histopathology but these methods are limited in terms of subjectivity, cost and time. There is an unmet clinical need for new methods to aid clinicians in the early detection of cervical pre-cancer. Raman spectroscopy has emerged as a promising new technology for cancer diagnosis and over the past 15 years, there have been numerous reports showing the potential of Raman spectroscopy together with multivariate statistical analysis for the detection of a variety of cancers, including cervical cancer.  This talk will discuss the potential of Raman spectroscopy for the elucidation of the biochemical changes associated with pre-malignant stages of cervical cancer.  Studies on the use of Raman spectroscopy for routine cervical cytology and histopathology will be presented.